CRF Seed Money Makes Research Grow and Cancer Rates Drop
Since 2000, Cigarette Restitution Fund (CRF)-sponsored researchers at Johns Hopkins have made significant inroads in understanding the cellular, genetic, and environmental causes of cancer. From genetic blueprinting to vaccine development, their work has been published in scientific journals and has been the subject of media reports. These successes serve as proof of principle—CRF investment in cancer research is paying off.
 In Maryland, cancer mortality rates have
been dropping twice the national average
since the state dedicated proceeds from
a multimillion dollar tobacco settlement
to cancer research, prevention, screening
and treatment programs. To view WJZ-TVs
coverage of CRF and its impact on Maryland
cancer rates, click here.
Following is a small sampling of CRF investigators whose research is already making headlines. For more information on recent CRF news, download CONQUEST, a report on the CRF funds at Johns Hopkins.
CRF Scientist Seek 'Swish and Spit' Test for Cancer
CRF researcher Joseph Califano is working to develop a test that could detect the presence of certain cancers of the head and neck based on compounds found in saliva. A simple mouth rinse could be all it takes to capture genetic signatures common to head and neck cancers.
CRF Scientists Create 3-D image of Cancer Initiator
A growth-promoting gene called PIK3CA, linked to cancer by CRF investigator Victor Velculescu, is believed to be one of the most frequently mutated in cancer, and now we know what the enemy looks like. A research team from the Johns Hopkins University created a 3-D picture of the gene and, onto the model, mapped all cancer-associated mutations.
CRF Scientist Identifies Mutations Linked to Hereditary Lung Disease
Kimmel Cancer Center investigators, including CRF-funded Mary Armanios, have identified the genetic culprits that trigger a hereditary form of a fatal lung disease. The findings may provide new directions in diagnosis and treatment for families that inherit genes for the disease, as well as for those that develop noninherited forms of the illness.
HPV Causing More Oral Cancer in Men
According to a new study by CRF researcher Maura Gillison, the sexually transmitted virus that causes cervical cancer in women is poised to become one of the leading causes of oral cancer in men. Gillison’s findings have attracted the attention of cancer experts worldwide.
CRF Researcher Develops Vaccine to Protect Against Cervical Cancer
A 2001 CRF grant has allowed Dr. Connie Trimble to launch a clinical unit to screen women for early stages of cervical cancer; develop and test a vaccine to protect against cervical cancer in women infected with human papillomavirus (HPV); and study the reasons women are still developing cervical cancer in a time when screening is widely available.
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